‘Fats’ Can Help in treating type 2 diabetes patients
A new research has discovered that the fats is a ‘new weapon’ in a war against type 2 diabetes and also it plays an important role in curing it.
According to Alan Saghatelian, Ph.D at the Salk Institute for Biological Studies with Barbara Kahn, M.D. , they have conducted the research and found that there is a new class of potentially therapeutic lipids, called fatty-acid esters of hydroxy fatty acids (FAHFAs), found in people with insulin resistance. The FAHFAs when administered to diabetic mice improved their glucose metabolism and also the insulin secretion, and opened an avenue for the development of novel medications for the disease.
Kahn’s team at Beth Israel Medical Deaconess Center found that they could make obese mice that were unusually sensitive to insulin and suspected that the lipids that were found in them were behind it. The research on these newly discovered fats can lead to a diabetes therapy.
Researchers have identified a total of 16 different types of FAHFAs in the mice by using the mass spectrometry technique. The lipids were then fed to insulin- resistant mice and observed that there had been an improvement in the inflammation, insulin sensitivity and the glucose uptake.
The researchers also calculated the FAHFA levels in the blood samples from human subjects, and found lower levels of these compounds in those with insulin resistance.
Saghatelian said that they are able to come up with better therapies to treat the disease with fewer side effects and that would be effective to a large number of people.
The research would be described recently at the 249th National Meeting and Exposition of the American Chemical Society (ACS).3